We thank all ICBS members for supporting and advancing chemical biology.

Below is the list of recent peer-reviewed publications published by ICBS members.

The authors who are ICBS members are highlighted in bold.

To submit your publication, please complete the form here.

2022

• Mala P, Saraogi I, Enhanced codon-anticodon interaction at in-frame UAG stop codon improves efficiency of non-natural amino acid mutagenesis. ACS Chem Biol, 2022, May 9,  https://doi.org/10.1021/acschembio.1c00782.

• Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, Cicka D, Yang X, Fan D, Reyna MA, Cooper LAD, Moreno CS, Zhou W, Owonikoko TK, Lonial S, Khuri FR, Du Y, Ramalingam SS, Mills GB, Fu H, Systematic discovery of mutation-directed neo-protein-protein interactions in cancer, Cell, 2022, May 4, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2022.04.014.

• Openy J, Amrahova G, Chang JY, Noisier A, 't Hart P. Solid-phase peptide modification via deaminative photochemical Csp3-Csp3 bond formation using Katritzky salts. Chemistry. 2022 Apr 19. doi: 10.1002/chem.202201121. Epub ahead of print. PMID: 35438838.

• Small JC, Joblin-Mills A, Carbone K, Kost-Alimova M, Ayukawa K, Khodier C, Dancik V, Clemons PA, Munkacsi AB, Wagner BK. Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity. ACS Chem Biol. 2022 Apr 19. doi: 10.1021/acschembio.2c00052. Epub ahead of print. PMID: 35439415

• Tian H, Gunnison KM, Kazmi MA, Sakmar TP, Huber T. FRET sensors reveal the retinal entry pathway in the G protein-coupled receptor rhodopsin. iScience. 2022 Mar 11;25(4):104060. doi: 10.1016/j.isci.2022.104060. PMID: 35355518.

• Wang J, Guo X, Wan L, Liu Y, Xue H, Zhao ZK. Engineering Formaldehyde Dehydrogenase from Pseudomonas putida to Favor Nicotinamide Cytosine Dinucleotide. Chembiochem. 2022 Apr 5;23(7):e202100697. doi: 10.1002/cbic.202100697. Epub 2022 Feb 19. PMID: 35146861.

• Han Y, Zhu J, Yang L, Nilsson-Payant BE, Hurtado R, Lacko LA, Sun X, Gade AR, Higgins CA, Sisso WJ, Dong X, Wang M, Chen Z, Ho DD, Pitt GS, Schwartz RE, tenOever BR, Evans T, Chen S. SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells. Circ Res. 2022 Apr;130(7):963-977. doi: 10.1161/CIRCRESAHA.121.320518. Epub 2022 Mar 8. PMID: 35255712.

• Chen H, Wu Y, Li K, Currie I, Keating N, Dehkhoda F, Grohmann C, Babon JJ, Nicholson SE, Sleebs BE. Optimization of Phosphotyrosine Peptides that Target the SH2 Domain of SOCS1 and Block Substrate Ubiquitination. ACS Chem Biol. 2022 Feb 18;17(2):449-462. doi: 10.1021/acschembio.1c00884. Epub 2022 Jan 6. PMID: 34989544.

• Chattopadhyay S, Teixeira LBC, Kiessling LL, McAnulty JF, Raines RT. Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing. ACS Chem Biol. 2022 Feb 18;17(2):314-321. doi: 10.1021/acschembio.1c00745. Epub 2022 Jan 27. PMID: 35084170.
  

• Shu C, Zheng X, Wuhafu A, Cicka D, Doyle S, Niu Q, Fan D, Qian K, Ivanov AA, Du Y, Mo X, Fu H. Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells. Acta Pharmacol Sin. 2022 Jan 14. doi: 10.1038/s41401-021-00847-6. Epub ahead of print. PMID: 35031699.

• Li X, Liu S, Li X, Li XD. YEATS Domains as Novel Epigenetic Readers: Structures, Functions, and Inhibitor Development. ACS Chem Biol. 2022 Jan 18. doi: 10.1021/acschembio.1c00945. Epub ahead of print. PMID: 35041380.

2021

• Cheng YS, Zhang T, Ma X, Pratuangtham S, Zhang GC, Ondrus AA, Mafi A, Lomenick B, Jones JJ, Ondrus AE. A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes. Nat Chem Biol. 2021 Dec;17(12):1271-1280. doi: 10.1038/s41589-021-00907-2. Epub 2021 Nov 19. PMID: 34799735.

• Gatin-Fraudet B, Ottenwelter R, Le Saux T, Norsikian S, Pucher M, Lombès T, Baron A, Durand P, Doisneau G, Bourdreux Y, Iorga BI, Erard M, Jullien L, Guianvarc'h D, Urban D, Vauzeilles B. Evaluation of borinic acids as new, fast hydrogen peroxide-responsive triggers. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2107503118. doi: 10.1073/pnas.2107503118. PMID: 34873034.

• Chinoy ZS, Montembault E, Moremen KW, Royou A, Friscourt F. Impacting Bacterial Sialidase Activity by Incorporating Bioorthogonal Chemical Reporters onto Mammalian Cell-Surface Sialosides. ACS Chem Biol. 2021 Nov 19;16(11):2307-2314. doi: 10.1021/acschembio.1c00469. Epub 2021 Sep 30. PMID: 34590826.

• Kowalski-Jahn M, Schihada H, Turku A, Huber T, Sakmar TP, Schulte G. Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain. Sci Adv. 2021 Nov 12;7(46):eabj7917. doi: 10.1126/sciadv.abj7917. Epub 2021 Nov 10. PMID: 34757789.

• Li X, Li XD. Integrative Chemical Biology Approaches to Deciphering the Histone Code: A Problem-Driven Journey. Acc Chem Res. 2021 Oct 5;54(19):3734-3747. doi: 10.1021/acs.accounts.1c00463. Epub 2021 Sep 23. Erratum in: Acc Chem Res. 2021 Dec 7;54(23):4449. PMID: 34553920.

• Wang Q, Bao X, Chen S, Zhong H, Liu Y, Zhang L, Xia Y, Kragler F, Luo M, Li XD, Lam HM, Zhang S. AtHDA6 functions as an H3K18ac eraser to maintain pericentromeric CHG methylation in Arabidopsis thaliana. Nucleic Acids Res. 2021 Sep 27;49(17):9755-9767. doi: 10.1093/nar/gkab706. PMID: 34403482.

• Tang C, Niu Q, Cicka D, Du Y, Mo X, Fu H. A time-resolved fluorescence resonance energy transfer screening assay for discovery of protein-protein interaction modulators. STAR Protoc. 2021 Sep 8;2(3):100804. PMID: 34527960.

• Yang X, Fan D, Troha AH, Ahn HM, Qian K , Liang B, Du Y, Fu H, Ivanov AA. Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer. Bioorg Med Chem. 2021 Sep 1;45:116324. doi: 10.1016/j.bmc.2021.116324. Epub 2021 Jul 22. PMID: 34333394.
  

• Clemons PA, Bittker JA, Wagner FF, Hands A, Dančík V, Schreiber SL, Choudhary A, Wagner BK. The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes. SLAS Discov. 2021 Aug;26(7):855-861. PMID: 34130532.

• Graham BJ, Windsor IW, Gold B, Raines RT . Boronic acid with high oxidative stability and utility in biological contexts. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2013691118. doi: 10.1073/pnas.2013691118. PMID: 33653951.
  

• Blosser SL, Sawyer N, Maksimovic I, Ghosh B, Arora PS. Covalent and Noncovalent Targeting of the Tcf4/β-Catenin Strand Interface with β-Hairpin Mimics. ACS Chem Biol. 2021 Aug 20;16(8):1518-1525. doi: 10.1021/acschembio.1c00389. Epub 2021 Jul 21. PMID: 34286954.

• Ogbede JU, Giaever G, Nislow C. A genome-wide portrait of pervasive drug contaminants. Sci Rep. 2021 Jun 14;11(1):12487. doi: 10.1038/s41598-021-91792-1. PMID: 34127714.

• Tang C, Mo X, Niu Q, Wahafu A, Yang X, Qui M, Ivanov AA, Du Y, Fu H. Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling. Cell Chem Biol. 2021 May 20;28(5):636-647.e5. PMID: 33326750.

• Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS; Cancer Target Discovery and Development Network. An expanded universe of cancer targets. Cell. 2021 Mar 4;184(5):1142-1155. doi: 10.1016/j.cell.2021.02.020. PMID: 33667368.

  Doherty EE, Wilcox XE, van Sint Fiet L, Kemmel C, Turunen JJ, Klein B, Tantillo DJ, Fisher AJ, Beal PA. Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. J Am Chem Soc. 2021 May 12;143(18):6865-6876. doi: 10.1021/jacs.0c13319. Epub 2021 May 3. PMID: 33939417.
  

• Kozicka Z, Thomä NH. Haven't got a glue: Protein surface variation for the design of molecular glue degraders. Cell Chem Biol. 2021 Jul 15;28(7):1032-1047. doi: 10.1016/j.chembiol.2021.04.009. Epub 2021 Apr 29. PMID: 33930325.

• Lin J, Bao X, Li XD. A tri-functional amino acid enables mapping of binding sites for posttranslational-modification-mediated protein-protein interactions. Mol Cell. 2021 Jun 17;81(12):2669-2681.e9. doi: 10.1016/j.molcel.2021.04.001. Epub 2021 Apr 23. PMID: 33894155.
  

• Jun JV, Raines RT. Two-Step Synthesis of α-Aryl-α-diazoamides as Modular Bioreversible Labels. Org Lett. 2021 Apr 16;23(8):3110-3114. doi: 10.1021/acs.orglett.1c00793. Epub 2021 Apr 5. PMID: 33818092.

• Wang X, Feng Y, Guo X, Wang Q, Ning S, Li Q, Wang J, Wang L, Zhao ZK. Creating enzymes and self-sufficient cells for biosynthesis of the non-natural cofactor nicotinamide cytosine dinucleotide. Nat Commun. 2021 Apr 9;12(1):2116. doi: 10.1038/s41467-021-22357-z. PMID: 33837188.

• Grigsby SM, Friedman A, Chase J, Waas B, Ropa J, Serio J, Shen C, Muntean AG, Maillard I, Nikolovska-Coleska Z. Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis. Cancers (Basel). 2021 Feb 5;13(4):642. doi: 10.3390/cancers13040642. PMID: 33562706.