Day 1- Tuesday, October 17, 2017

Young Chemical Biologists’ Forum (Auditorium)

Chairs: Xiaoguang Lei, ICBS2013 YCB, Peking University

Qi Zhang, Fudan University

Women Chemical Biological Scientist forum

(Conference Room)

Chairs: Zaneta Nikolovska-Coleska, University of Michigan, USA

Xu Zhang, Nanjing University of Chinese Medicine

8:30-8:50 A shotgun Approach to inquire degradable

kinome

Li Tan, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China

8:50-9:10 XFEL for structural chemical biology of

GPCRs

Haitao Zhang, Zhejiang University, China

9:10-9:40 Exploring Complex Protein Structures and

Protein-Protein Interactions with CXMS

Xiaoguang Lei (YCB2013), Peking University, China

9:40-10:00 Chemoproteomic Profiling Reveals the Anti

steatosis Mechanism of Traditional Chinese

Medicine

Chu Wang, Peking University, China

8:30-9:00 Enzyme and Pathway Design for Efficient

Biosynthesis

Yan Feng, Shanghai Jiao Tong University, China

9:00-9:30 Mechanistic investigation of herbal

medicine and compounds on NSCLC

Xu Zhang, Nanjing University of Chinese Medicine, China

9:30-10:00 Physiologically relevant 3D model system for chemical biology screening

Yuhong Du, Emory University School of Medicine, USA

10:00-10:15 Coffee Break

10:15-10:45 Small-molecule stabilization of protein

protein interactions

Christian Ottmann (YCB2013), Eindhoven University of Technology, Netherlands

10:45-11:05 Biosynthesis of PP2A inhibitor Rubratoxin A

Youcai Hu, Institute of Materia Medica,

Chinese Academy of Medical Sciences & Peking Union Medical College, China

11:05-11:35 Regulation and targeting of BAX-mediated

apoptosis

Evripidis Gavathiotis (YCB2014), Albert Einstein College of Medicine, USA

11:35-11:55 Mechanistic Studies of a Multifunctional 2- Oxoglutarate Dependent Non-heme Iron

Enzyme, AsqJ

Yisong Guo, Carnegie Mellon University, USA

11:55-12:10 5M strategy guided metabolic engineering

of high-yield Rhodobacter Sphaeroides for

co-enzyme Q10 overproduction

Gaoyi Tan, East China University of

Science and Technology, China

10:15-10:45 Zaneta Nikolovska-Coleska, University of Michigan, USA

10:45-11:00 Fragment Based Approaches Towards

the Development of CoaBC Inhibitors as

Novel Antimicrobial Drugs

Jeannine Hess, Department of

Chemistry, University of Cambridge, UK

11:00-11:15 Sequential deletions of the chromosome I of Saccharomyces cerevisiae by

constructing a small chromosome

Min Zhou, Shanghai Institutes for

Biological Science, China

11:15-11:30 Downregulation of Kinase by ATP-competitive Kinase inhibitors

Li Jing, Pfizer Inc, USA

11:30-11:45 Decipher and harnessing of the programmed triacylglycerols bridge for titer improvement of polyketides in Streptomyces

Shanshan Li, Institute of Plant Protection,Chinese Academy of Agricultural Sciences

11:45-12:00 Genomic Insights into Diversity of TPS and the Terpenoids of Pathogenic Fungi

Jingyu Zhang, East China University of

Science and Technology, China

12:00-13:20 Lunch (posters by odd number/exhibition session)

13:20-13:40 Protein chemical Synthesis for further ubiquitin code and histone ubiquitin code

analysis

Changlin Tian, School of Life Sciences, University of Science and Technology of China, China

13:40-14:00 Mechanistic investigation of radical S- adenosylmethionine enzymes

Qi Zhang, Fudan University, China

14:00-14:30 Development of far-red to near-infrared

small-molecules fluorophores and their application to fluorescent probes

Kenjiro Hanaoka (YCB2014), The University of Kokyo, Japan

14:30-15:00 Electrophysiology, Unplugged: Using Chemistry to Watch Cells in Action

Evan Miller (YCB2015), University of California- Berkeley, USA

15:00-15:30 Inspiration from Fluorination: Chemical

Biology Approaches to Probe Molecular

Recognition Events in Transcription

William Pomerantz (YCB2016), University of Minnesota Twin Cities, USA

15:30-16:00 Group Photo (Yifu Building)

NOTE: Raining day upon notice

DAY 2 – Wednesday, October 18, 2017

8:30-11:30 ICBS President’s forum and Round table discussion (Auditorium)

Synthetic Biology to drive chemical biology and biotechnology

Chairs: Jens Nielsen and George Guo-Qiang CHEN

Production of non-natural chemicals by metabolic engineering

Sang Yup Lee, Korea Advanced Institute of Science and Technology, Korea

Next Generation Industrial Biotechnology based on Halophiles

George Guo-Qiang Chen, Tsinghua University, China

Synthetic biology of yeast for production of fuels and chemicals

Jens Nielsen, Chalmers University of Technology, Sweden

Harnessing synthetic biology for fine and speciality chemical production

Eriko Takano, University of Manchester, UK

Engineering of Optogenetic Designer Human Cells for Diabetes Therapy

Haifeng Ye, East China Normal University, China

9:45-11:30 Panel discussion on Development of Commercialization of Synthetic Biology

11:30-13:00 Lunch (Posters by odd number/exhibition session/State Key Laboratory of Bioreactor Engineering tour)

I. Chemical innovations to expand chemical space and reach the undruggables

Session 1: Expand the chemical space (Auditorium)

Chairs: Jason Micklefield, The University of Manchester, UK

Huw Davies, Emory University, USA

13:00-13:25 Mechanistic studies of the cyclization reactions in the biosynthesis of spinosyn

Hung-wen (Ben) Liu, University of Texas at Austin, USA

13:25-13:50 Heterologous Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in Streptomyces

Eung-Soo Kim, Inha University, South Korea

13:50-14:15 Diversification of bioactive natural and non-natural products using engineered biosynthetic pathways

and enzymes

Jason Micklefield, The University of Manchester, UK

14:15-14:40 Genetically encoding phosphotyrosine and its nonhydrolyzable analog

Feng Wang, California Institute for Biomedical Research, USA

14:40-15:05 Beyond orthogonality, another good reaction for click chemistry

Jiajia Dong, Shanghai Institute of Organic Synthesis, China

15:05-15:30 Collaborative approaches for selective C-H functionalization

Huw Davies, Emory University, USA

15:30-15:45 Coffee Break

Session 2: New chemical modalities (Auditorium)

Chairs: Xiyun Yan, Institute of Biological Physics, Chinese

Academy of Sciences, China

Zhen Xi, Nankai University, China

Session 3: Chemical biology to address undruggable targets (Conference Room)

Chairs: Tom Pfeifer, CDRD, Canada

Jiangyun Wang, Institute of Biophysics, Chinese Academy of Sciences, China

15:45-16:10 Nanozyme: discoveryand itsapplications

in medicine

Xiyun Yan, Institute of Biological Physics, Chinese Academy of Sciences, China

16:10-16:35 Chemoenzymatic glycan labeling:

methods and applications

Peng Wu, John Hopkins University, USA

16:35-17:00 MetDNA: Recursive Metabolite

Annotation and Dysregulated Network Analysis for Untargeted Metabolomics

Zhengjiang Zhu, Shanghai Institute of Organic Chemistry, China

17:00-17:25 Ribosome pausing at AT-rich codons

regulates translation in Streptomyces

tsukubaensis

Byung-Kwan Cho, Korea Advanced Institute of Science and Technology (KAIST), Republic of Korea

17:30-18:30 Posters by odd number/exhibition session

18:30-20:00 Dinner (Youyi restaurant)

Day 3- Thursday, October 19, 2017

I. Addressing challenges in diseases with chemical biology

8:30-9:15 Keynote address (Auditorium)

Expanding antibiotic chemical space baed on bacterial biodiversity to fight antimicrobial resistance

Rolf Müller, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Germany

Session 4: Determine molecular mechanisms of an active compound (Auditorium)

Chair: Bridget Wagner, Broad Institute of MIT and Harvard, USA

Seung Bum Park, Seoul National University, South Korea

9:15-9:40 Systematic approaches to small-molecule

mechanism-of-action studies

Bridget Wagner, Broad Institute of MIT and Harvard, USA

9:40-10:05 Screening and target identification of small molecules affecting cancer metabolism

Hiroyuki Osada, RIKEN, Japan

10:05-10:30 FITGE-based Target Identification: New Tool in Chemical Biology

Seung Bum Park, Seoul National University, Korea

10:30-10:45 Coffee Break

10:45-11:10 Function of CDK1-TIP60-Aurora B axis in

cell fate decision control

Xuebiao Yao, University of Science and Technology of China

11:10-11:25 Chemical Proteomics Reveal Bioactive Mechanism of Natural Products through Activity-based Protein

Profiling Strategy

Youli Xiao, CAS Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular

11:25-11:40 Novel mechanism of action of an anti-biofilm antibiotic

Chengzhang Fu, Helmholtz Institute for

Pharmaceutical Research Saarland

(HIPS), Germany

11:40-11:55 Resistance Mechanisms to mTOR Kinase Inhibitors in Cancer

X.F. Steven Zheng, Rutgers Cancer Institute of New Jersey, USA

11:55-12:10 Fueling metabolism one reaction at a time

Zongbao Kent Zhao, Dalian Institute of Chemical Physics, China

10:45-12:00 Global chemical biology landscape – an update (Conference Room)

Chair: Masatoshi Hagiwara, University of Kyoto, Japan

The Japanese Society for Chemical Biology

Masatoshi Hagiwara, University of Kyoto, Japan

Chemical biology in China

Lihe Zhang, Peking University, China

Graduate Chemical Biology education in the US

Zaneta Nikolovska-Coleska, University of Michigan, USA

EU-OpenScreen and chemical biology in Europe

Bahne Stechmann, EU-OPENSCREEN, Berlin, Germany

Updates on chemical biology societies and activities around the globe

12:00-13:30 Lunch (Posters by even number/exhibition session)

13:30-14:15 Keynote address (Auditorium)

RNA-targeting chemical therapeutics

Masatoshi Hagiwara, Kyoto University, Japan

Session 5: Interrogate diseases with chemical biology Ⅰ(Auditorium)

Chairs: Guo-Qiang Chen, Shanghai Jiaotong University, China

Jonathan Baell, Monash University, Australia

Session 6: Interrogate diseases with chemical biology Ⅱ (Conference Room)

Chairs: Hanne Ingmer, University of Copenhagen,

Denmark

Cong Liu, Shanghai Institute of Organic Chemistry, China

14:15-14:40 Cancer cell fate determination-based

chemical biology investigation

Guo-Qiang Chen, Shanghai Jiaotong University, China

14:40-15:05 Discovery of first-in-class specific small

molecules antagonizing PXR(NR112) to overcome drug resistance in human cancers

Taosheng Chen, St Jude Children’s Research Hospital, USA

14:15-14:40 A general methodology for conversion of

life-threatening viruses into live virus vaccines

Demin Zhou, Peking University, China

14:40-15:05 Interplay between a-synuclein and lipid

in Parkinson’s disease

Cong Liu, Shanghai Institute of Organic Chemistry, China

15:05-15:20 Coffee Break

15:20-15:45 Novel small molecule MerTK inhibitors

and their dual function in cancer treatment

Xiaodong Wang, The University of North Carolina at Chapel Hill, USA

15:45-16:10 Spatiotemporal control cellular functions by environment stimuli-induced proximity

Wei Wang, East China University of

Science and Technology, China

16:10-16:35 Design and development of

slycosyltransferase inhibitors as novel anti

metastatic agents

Danielle Skropeta, University of Wollongong, Australia

16:35-17:00 Aglycone polyethersJ1-001 and itshomologues are effective tobroad cancer cells

Tiangang Liu, Wuhan University, China

17:00-17:15 Identification and functional

characterization of novel xylose

transporters from Trichoderma reesei

Xu Fang, Shandong University, China

17:15-17:35 Identifying miRNAs that influence cancer cell growth and chemotherapeutic sensitivity

Robert (Bob) Lund, BeckMan Coulter

15:20-15:45 Natural quorum quenching compounds

targeting Staphylococcus aureus quorum sensing- implications for colonization and infection

Hanne Ingmer, University of Copenhagen, Denmark

15:45-16:00 Protein aggregation small molecule

inhibitor discovery and mechanisms

Bin Xu, School of Neuroscience, Virginia Tech, USA

16:00-16:15 Cytotoxic protein from the mushroom Coprinus comatus possesses a unique glycan binding fold and specificity

Yousong Ding, University of Florida, USA

16:15-16:30 Generation of click-able kirromycin derivatives by exploiting the substrate promiscuity of the discrete acyl transferase KirCII

Tilmann Weber, Technical University of

Denmark, Denmark

16:30-17:30 Special session: Chemical biology in pharmaceutical industry (Conference Room)

Chair: Christian Ottmann, Eindhoven University of Technology, Netherlands

Panelists: Yves Auberson, Novartis, Switzerland

Rathnam Chaguturu, iDDPartners, USA

Hong Shen, Roche Innovation Center, China

Takashi Owa, Eisai Co., Ltd., Japan

Yanwen Liu, SPRIM China Company, USA

17:30-18:30 Posters by even number/exhibition session

18:30-20:00 Dinner (Youyi restaurant)

Day 4 – Friday, October 20, 2017

I. Chemical biology innovations and applications

Session 7: Biological insights with chemical biology (Auditorium)

Chairs: Tapas Kundu, JCASR, India

Siddhartha Roy, Boss Institute, India

Session 8: Molecular biosensors and actuators (Conference Room)

Chair: Jin Zhang, University of California San Diego, USA

8:30-8:55 Protein degradation based conditional

knockout

Pinghua Liu, Boston University, USA

8:55-9:20 Crosstalk between epigenetic systems in

bacteria

Shi Chen, Wuhan University, China

9:20-9:45 Chemical-assisted sequencing of

epigenetic nucleic acid modifications

Chengqi Yi, Peking University, China

9:45-10:10 Structural insights of electron transfer

in P450 monooxygenase

Jiahai Zhou, Shanghai Institute of Organic Chemistry, China

8:30-8:55 NIR Fluorescent Organic Nanoprobes

Weihong Zhu, East China University of Science and Technology, China

8:55-9:20 Making gels in cells: total synthesis of

stress granules by multivalent enhancers

Takanari Inoue, Johns Hopkins University, USA

9:20-9:45 Protein engineering and the development

of intracellular biosensors

Robert Campbell, University of Alberta,

Canada

9:45-10:10 Genetically encoded fluorescent sensors

reveal dynamic regulation of redox metabolism in living cells

Yi Yang, East China University of Science

And Technology, China

10:10-10:20 Coffee Break

Session 9: Emerging technologies (Auditorium)

Chairs: Mikiko Sodeoka, RIKEN, Japan

Peng Chen, Peking University, China

Session 10: Computational approaches to accelerate chemical biology research (Conference Room)

Chairs: Luhua Lai, Peking University, China

Petr Bartunek, Institute of Molecular Genetics, Czech Republic

10:20-10:45 Bioorthogonal cleavage reactions in

living cells

Peng Chen, Peking University, China

10:45-11:10 Perturbation of microtubule function

using designed peptides

Surajit Ghosh, CSIR-IICB, India

11:10-11:25 Structural investigations on multiple steps of viral DNA cytidine deamination

Chunyang Cao, Institute of Organic Chemistry, University of Chinese Academy of Sciences

11:25-11:40 Selective labelling and eradication of antibiotic-tolerant populations in bacterial biofilms

Liang Yang, Nanyang Technological

University, Singapore

11:40-12:05 Turn-on fluorescent labeling using O

NBD unit

Mikiko Sodeoka, RIKEN, Japan

10:20-10:50 Chemical and biological space exploration

Petr Bartunek, Institute of Molecular Genetics, Czech Republic

10:50-11:15 Rational design of protein allosteric

regulators

Luhua Lai, Peking University China

11:15-11:40 Evolution of chemical similarity: from

structure to activity

Paul A. Clemons, Broad Institute of MIT and Harvard, USA

11:40-11:55 Antimicrobial Nylon-3 Polymers as Synthetic Mimics of Host Defense Peptide

Runhui Liu, East China University of Science and Technology, China

12:00-13:30 Lunch

13:30-14:30 Rising stars in chemical biology: ICBS Young Chemical Biologist awards 2017 (Auditorium)

Chair: Haian Fu, Emory University, USA

14:30-15:15 Closing Keynote address (Auditorium)

Biological applications of SuFEX click chemistry

K. Barry Sharpless, 2001 Nobel Prize in Chemistry, The Scripps Research Institute, La Jolla, USA

15:15-16:00 ICBS Business meeting (Auditorium)

16:00- Shuttle bus to the Bund

17:30-21:00 Banquet, award and performance (The Bund 22, Huangpu District)