Co-hosted by: Japanese Society for Chemical Biology (JSCB)

Pre-Meeting Educational Course for Chemical Biology and Drug Discovery, 7 October

Download a recent list of chairperson and speaker biographies.

The final schedule:

Keynote Lectures

James Wells, University of California San Francisco, USA

"Challenging Targets for Chemical Biologists"

Shuh Narumiya, Kyoto University, Japan

"Academia-Industry Alliance for Drug Discovery and Development; Challenge and Experience of Kyoto University”

Schedule and Speakers

7 October

17:00 - 17:10     Opening Remarks

17:10 - 17:55     Keynote Lecture: 
James Wells, University of California San Francisco, USA
"Challenging Targets for Chemical Biologists"

17:55 - 19:30     Session I: Cutting Edge Medicinal Chemistry and Tool Compounds

Chair: Nobutaka Fujii, Kyoto University, Japan

• Huw Davies, Emory University, USA
  Impact of New Enabling Technologies from Organic Synthesis on Chemical Biology
• Shudong Wang, University of South Australia
  Targeting Cancer with Small Molecule Kinase Inhibitors
• Jiang Wu, Lanzhou University, China
  Chemical Inhibitors of the Histone Acetyltransferase
• Yukihiro ltoh, Kyoto Prefectural University of Medicine, Japan
  Design and Synthesis of LSD1 Inactivators Based on Enzyme-Targeted Drug Delivery Mechanism

8 October

9:00 - 10:25     Session II: Chemical Imaging

Chair: Tetsuo Nagano, University of Tokyo, Japan

• Yasuteru Urano, University of Tokyo, Japan
  Novel Intramolecular Spirocyclization-based Fluorogenic Probes: From In Vivo Imaging of Tiny Tumors to Super-resolution Imaging
  
• Lin Li, National University of Singapore, Singapore
  Two-photon Small Molecular Enzymatic Probes
• Christopher J. MacNevin, University of North Carolina, USA
  The small molecule based biosensor CaMero reports calmodulin activation dynamics in vivo
• Shimpei Iwaki, The University of Tokyo, Japan
  Development of a Gd3+-based MRI contrast agent for Atherosclerotic plaques
• Yuko Kamikawa, Osaka University, Japan
  Development of PYP-tag mutants For protein labeling with fluorogenic probe
  Wen Piao, The University of Tokyo, Japan
  Development of Azo-based Hypoxia-sensitive Fluorescent Probes with Different Oxygen Sensitivity
  

10:25 - 10:35     Coffee/Tea Break

10:35 - 11:55     Session III: Chemical Systems Biology/Chemoinformatics & Modeling

Co-chairs: Jürgen Bajorath, Rheinische Friedrich-Wilhelms-Universität Bonn, Germany
Dr. Petr Bartunek, Institute of Molecular Genetics of the ASCR VVVI, Czech Republic

• Weiliang Zhu, Shanghai Institute of Materia Medica, China
  Halogen bond and its role in and beyond lead discovery and optimization
• Lansing Taylor, University of Pittsburgh, USA
  Quantifying heterogeneity in the Response of Cells to Challenges: Development of an Index
• Zaneta Nikolovska-Coleska, University of Michigan, USA
  Identification, structure-based design and development of novel small molecule inhibitors of Mcl-1
• Sergey Shityakov, University of Würzburg, Germany
  Pharmacokinetic delivery modeling of nicardipine incorporated in hydrophobic and hydrophilic cyclodextrin formulations using Matlab and Maple software packages
• Univ.-Prof. Dr. Jürgen Bajorath, University of Bonn, Germany
  Compound data mining in systems chemical biology: exploring multi-target activityspaces and compound promiscuity patterns
  

11:55 - 13:00      Lunch

13:00 - 14:35     Session IV: Global Natural Product Resources: Unique Features, Collaboration Models and Success Stories

Chair: Ron Quinn, Griffith University, Australia

• Ron Quinn, Griffith University, Australia
  Nature Bank a Global Natural Product Resource: Unique Features, Collaboration Models, and Success Stories
  
• Hakim Djaballah, Memorial Sloan-Kettering Cancer Center, USA
  Natural Product Research in the MSKCC and the U.S.
• Hiroyuki Osada, Riken, Japan
  Isolation of new microbial metabolites for Natural product depository (NPDepo)
• Lixin Zhang, Chinese Academy of Sciences, China
  Promoting chemical Biology and Drug Discovery by Leveraging Natural Product Resources in China: Case Studies
• Kozo Yoneda, University of Tsukuba, Japan
  Novel Protein-protein Interaction Induced by the Marine Natural Product Aplyronine A

14:35 - 14:45     Coffee/Tea Break

14:45 - 15:30     Session V: Phenotypic Screening, Target Identification and Associated Novel Technologies

Chair: Hakim Djaballah, Memorial Sloan-Kettering Cancer Center, USA

• Seung Bum Park, Seoul National University, Korea
  FITGE-based target identification for the connection of rational drug discovery with phenotypic screening
• Maho Morita, Keio University, Japan
  Screening-inspired Study on the Biological Mechanism of Marine Natural Products Biselyngbyasides
• Liang Schweizer, Bristol-Myers Squibb, USA
  Novel Technology and process approaches to phenotypic screenings applying annotated compound libraries

15:30 - 16:15    Session VI: Chemical Biology Outside of Drug Discovery

Co-chairs: Melvin Reichman, LIMR Chemical Genomics Center, USA
David Nes, Texas Tech, Lubbock, Texas, USA

• Melvin Reichman, LIMR Chemical Genomics Center, USA
  Overview
  
• David Nes, Texas Tech, Lubbock, Texas, USA
  Exploring Chemodiversity and Function for Phytosterols
• Motonari Uesugi, Kyoto University, Japan
  Small Molecules for Cell Biology and Cell Therapy

16:15 - 17:20     Poster Briefing

17:20 - 19:30     Poster Presentation and Social Mixer

19:30 - 20:30     Business Meeting

9 October

9:00 - 10:30      Session VII: Chemical Genetics/Chemoproteomics

Chair: Masatoshi Hagiwara, Kyoto University, Japan

• Laurent Meijer, Centre National de la Recherche Scientifique, France
  Neuroprotective properties, selectivity and co-crystal structures of Leucettines, a family of DYRKs & CLKs kinases inhibitors derived from the marine sponge alkaloid Leucettamine B
• Isao Kii, Kyoto Unoversity, Japan
  A Novel Type of kinase inhibitor that Targets the folding intermediate of DYRK1A
• Stephanie Bellmaine, The University of Melbourne, Australia
  Dual-specificity tyrosine phosphorylation-regulated Kinase (DYRK) Action in stem cell differentiation and Self-renewal
• Xin Ku, Technische Universität München, Germany
  New Affinity Probes for Proteomic Selectivity Profiling of FGFR Inhibitors
• Pamela Lochhead, The Babraham Research Institute, UK
  Studies with a Novel DYRK1B Inhibitor Demonstrate that DYRK1B Phosphorylates Cyclin D1 at Threonine-286, not Threonine-288, to Promote its Proteasomal Degradation

10:20 - 10:30     Coffee/Tea Break

10:30 - 11:15     Session VIII: Neglected Diseases and Global Health
Chair: Lixin Zhang, Chinese Academy of Sciences, China

• Tanya Parish, Infectious Disease Research Institute, USA
  Development of novel azole series active against *Mycobacterium Tuberculosis as Probes to identify vulnerable metabolic pathways for drug discovery
• Babak Javid, Tsing Hua University, China
  A small molecule screen targeting mycobacterial translational fidelity
• Lars G. J. Hammarström, Karolinska Institutet, Sweden
  The Delicate SAR of Cordycepins as Experimental Therapeutics for Human African Trypanosomiasis
• Parasuraman Jaisankar, CSIR-Indian Institute of Chemical Biology, India
  3,3’-Diindolylmethane (DIM) as potent anti-leishmanial agent targeting DNA Topoisomerase 1B of Leishmania Donovani

11:15 - 12:00     Keynote Lecture II:
Shuh Narumiya, Kyoto University, Japan

"Academia-Industry Alliance for Drug Discovery and Development; Challenge and Experience of Kyoto University"

12:00 - 13:00     Lunch

13:00 - 14:00     Industry-Academic-Government Interaction in Drug Discovery
(Panel Discussion)

Co-chairs: Paul Bauer, Novartis, USA
Rathnam Chaguturu, SRI, USA

Panelists:

• Paul Bauer, Novartis, USA
  
• Tanya Parish, Infectious Disease Research Institute, USA
  
• Bahne Stechmann, Germany
  
• Tsutomu Kamiyama, Mitsubishi Tanabe Pharma and Kobe University, Japan
• Rathnam Chaguturu, SRI, USA

14:00 - 15:50      Session IX: Chemical Approaches for Translational Sciences

Chair: Siddhartha Roy, Indian Institute of Chemical Biology, India

• Mei Lin Go, National University of Singapore, Singapore
  Dibenzylidenethiopyranone Dioxides Induce APL Cell Apotosis by Proteasomal Inhibition and Activation of Endoplasmic Reticulum (ER) Stress Signaling Pathways
• Ling-Hua Meng, Chinese Academy of Sciences, China
  Targeting PI3K-coupled MEK/ERK Pathway for Therapy in Pediatric B Cell Acute lymphocytic leukemia 
• Tapas K. Kundu, Jawaharlal Nehru Centre for Advanced Scientific Research, India
  Chromatin Modifications in Neural Differentiation and Memory: Implications of Lysine Acetylation and Arginine Methylation
  
• Zhong-Yin Zhang, Indiana University, USA
  Drugging the Undruggable: Therapeutic Potential of Protein Tyrosine Phosphatases
• Guillaume Lessene, Walter and Eliza Hall Institute of Medical Research, Australia
  Small Molecules Interfering with Programmed Cell Death

15:50 - 16:00     Coffee/Tea Break

Chair: Haian Fu, Emory University, USA

• Bradley L. Pentelute, Massachusetts Institute of Technology, USA
  Novel Chemical Entities Introduced Into Cells via a Bacterial Transporter
• Christian Ottmann, Eindhoven University of Technology, Netherlands
  Small-molecule Stabilization of 14-3-3 Protein-Protein Interactions
• Xiaoguang Lei, National Institute of Biological Sciences, China
  Probing Programmed Cell Death with Bioactive Small Molecules  

17:30 - 17:50     Closing Lecture: "From Drugs to Genes: Implementing Target Free Approaches in Cancer Drug Discovery"

Ulf Nehrass, Franco-German Advanced Translational Center in Strasbourg (FGATC), France

17:50 - 18:00     Poster Awards, supported by CSBJ

18:00 - 18:15     Closing Remarks

ICBS would like to thank the following sponsors for their generous support: