In 2006, Shinya Yamanaka and Kazutoshi Takahashi reported the Nobel Prize winning discovery of induced pluripotent stem cells (iPSCs) in Cell. In the ten years that have passed since, iPSC technology has provided fundamental insights into our understanding of cell fate, mammalian development, and human disease. It has also spurred renewed interest in direct reprogramming across lineages, and this area too has flourished. Progress in understanding the biology of iPSCs and reprogramming has moved in parallel with work on clinical translation to apply the insights obtained, and the first iPSC-based clinical trials are already underway.

To mark the 10th anniversary of this landmark discovery, Cell Press is pleased to announce a symposium focused on iPSC research and applications.

We are excited to bring together leaders in biology, medicine, and industry to give an up-to-date view of this exciting and rapidly moving area. At this meeting, you can expect to hear about the latest advances in technology development, mechanistic understanding, and therapeutic application of reprogramming for both drug development and cell-based therapy. Our goal is that this meeting will serve as a catalyst for new ideas and future growth as the iPSC and reprogramming field enters its second decade.

Relevant themes include:

• Mechanisms of reprogramming
• Disease modeling and drug discovery
• Direct reprogramming
• Technology development
• Clinical translation