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Program for ICBS2013
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Co-hosted by: Japanese Society for Chemical Biology (JSCB)


Pre-Meeting Educational Course for Chemical Biology and Drug Discovery, 7 October

 

Download a recent list of chairperson and speaker biographies.

 

The final schedule:

 

Keynote Lectures

James Wells, University of California San Francisco, USA

"Challenging Targets for Chemical Biologists"


Shuh Narumiya, Kyoto University, Japan

"Academia-Industry Alliance for Drug Discovery and Development; Challenge and Experience of Kyoto University”

 

Schedule and Speakers

 

7 October

17:00 - 17:10     Opening Remarks

 

17:10 - 17:55     Keynote Lecture: 
James Wells, University of California San Francisco, USA
"Challenging Targets for Chemical Biologists"

 

17:55 - 19:30     Session I: Cutting Edge Medicinal Chemistry and Tool Compounds

Chair: Nobutaka Fujii, Kyoto University, Japan

  • Huw Davies, Emory University, USA
    Impact of New Enabling Technologies from Organic Synthesis on Chemical Biology
  • Shudong Wang, University of South Australia
    Targeting Cancer with Small Molecule Kinase Inhibitors
  • Jiang Wu, Lanzhou University, China
    Chemical Inhibitors of the Histone Acetyltransferase
  • Yukihiro ltoh, Kyoto Prefectural University of Medicine, Japan
    Design and Synthesis of LSD1 Inactivators Based on Enzyme-Targeted Drug Delivery Mechanism



8 October

9:00 - 10:25     Session II: Chemical Imaging

Chair: Tetsuo Nagano, University of Tokyo, Japan

  • Yasuteru Urano, University of Tokyo, Japan
    Novel Intramolecular Spirocyclization-based Fluorogenic Probes: From In Vivo Imaging of Tiny Tumors to Super-resolution Imaging
  • Lin Li, National University of Singapore, Singapore
    Two-photon Small Molecular Enzymatic Probes
  • Christopher J. MacNevin, University of North Carolina, USA
    The small molecule based biosensor CaMero reports calmodulin activation dynamics in vivo
  • Shimpei Iwaki, The University of Tokyo, Japan
    Development of a Gd3+-based MRI contrast agent for Atherosclerotic plaques
  • Yuko Kamikawa, Osaka University, Japan
    Development of PYP-tag mutants For protein labeling with fluorogenic probe
    Wen Piao, The University of Tokyo, Japan
    Development of Azo-based Hypoxia-sensitive Fluorescent Probes with Different Oxygen Sensitivity

 

10:25 - 10:35     Coffee/Tea Break

 

10:35 - 11:55     Session III: Chemical Systems Biology/Chemoinformatics & Modeling

Co-chairs: Jürgen Bajorath, Rheinische Friedrich-Wilhelms-Universität Bonn, Germany
Dr. Petr Bartunek, Institute of Molecular Genetics of the ASCR VVVI, Czech Republic

  • Weiliang Zhu, Shanghai Institute of Materia Medica, China
    Halogen bond and its role in and beyond lead discovery and optimization
  • Lansing Taylor, University of Pittsburgh, USA
    Quantifying heterogeneity in the Response of Cells to Challenges: Development of an Index
  • Zaneta Nikolovska-Coleska, University of Michigan, USA
    Identification, structure-based design and development of novel small molecule inhibitors of Mcl-1
  • Sergey Shityakov, University of Würzburg, Germany
    Pharmacokinetic delivery modeling of nicardipine incorporated in hydrophobic and hydrophilic cyclodextrin formulations using Matlab and Maple software packages
  • Univ.-Prof. Dr. Jürgen Bajorath, University of Bonn, Germany
    Compound data mining in systems chemical biology: exploring multi-target activityspaces and compound promiscuity patterns

 

11:55 - 13:00      Lunch

 

13:00 - 14:35     Session IV: Global Natural Product Resources: Unique Features, Collaboration Models and Success Stories

Chair: Ron Quinn, Griffith University, Australia

  • Ron Quinn, Griffith University, Australia
    Nature Bank a Global Natural Product Resource: Unique Features, Collaboration Models, and Success Stories
  • Hakim Djaballah, Memorial Sloan-Kettering Cancer Center, USA
    Natural Product Research in the MSKCC and the U.S.
  • Hiroyuki Osada, Riken, Japan
    Isolation of new microbial metabolites for Natural product depository (NPDepo)
  • Lixin Zhang, Chinese Academy of Sciences, China
    Promoting chemical Biology and Drug Discovery by Leveraging Natural Product Resources in China: Case Studies
  • Kozo Yoneda, University of Tsukuba, Japan
    Novel Protein-protein Interaction Induced by the Marine Natural Product Aplyronine A

 

14:35 - 14:45     Coffee/Tea Break

 

14:45 - 15:30     Session V: Phenotypic Screening, Target Identification and Associated Novel Technologies

Chair: Hakim Djaballah, Memorial Sloan-Kettering Cancer Center, USA

  • Seung Bum Park, Seoul National University, Korea
    FITGE-based target identification for the connection of rational drug discovery with phenotypic screening
  • Maho Morita, Keio University, Japan
    Screening-inspired Study on the Biological Mechanism of Marine Natural Products Biselyngbyasides
  • Liang Schweizer, Bristol-Myers Squibb, USA
    Novel Technology and process approaches to phenotypic screenings applying annotated compound libraries

 

15:30 - 16:15    Session VI: Chemical Biology Outside of Drug Discovery

Co-chairs: Melvin Reichman, LIMR Chemical Genomics Center, USA
David Nes, Texas Tech, Lubbock, Texas, USA

  • Melvin Reichman, LIMR Chemical Genomics Center, USA
    Overview
  • David Nes, Texas Tech, Lubbock, Texas, USA
    Exploring Chemodiversity and Function for Phytosterols
  • Motonari Uesugi, Kyoto University, Japan
    Small Molecules for Cell Biology and Cell Therapy

 

16:15 - 17:20     Poster Briefing

 

17:20 - 19:30     Poster Presentation and Social Mixer

 

19:30 - 20:30     Business Meeting

 

 

9 October

9:00 - 10:30      Session VII: Chemical Genetics/Chemoproteomics

Chair: Masatoshi Hagiwara, Kyoto University, Japan

  • Laurent Meijer, Centre National de la Recherche Scientifique, France
    Neuroprotective properties, selectivity and co-crystal structures of Leucettines, a family of DYRKs & CLKs kinases inhibitors derived from the marine sponge alkaloid Leucettamine B
  • Isao Kii, Kyoto Unoversity, Japan
    A Novel Type of kinase inhibitor that Targets the folding intermediate of DYRK1A
  • Stephanie Bellmaine, The University of Melbourne, Australia
    Dual-specificity tyrosine phosphorylation-regulated Kinase (DYRK) Action in stem cell differentiation and Self-renewal
  • Xin Ku, Technische Universität München, Germany
    New Affinity Probes for Proteomic Selectivity Profiling of FGFR Inhibitors
  • Pamela Lochhead, The Babraham Research Institute, UK
    Studies with a Novel DYRK1B Inhibitor Demonstrate that DYRK1B Phosphorylates Cyclin D1 at Threonine-286, not Threonine-288, to Promote its Proteasomal Degradation

 

10:20 - 10:30     Coffee/Tea Break

 

10:30 - 11:15     Session VIII: Neglected Diseases and Global Health
Chair: Lixin Zhang, Chinese Academy of Sciences, China

  • Tanya Parish, Infectious Disease Research Institute, USA
    Development of novel azole series active against *Mycobacterium Tuberculosis as Probes to identify vulnerable metabolic pathways for drug discovery
  • Babak Javid, Tsing Hua University, China
    A small molecule screen targeting mycobacterial translational fidelity
  • Lars G. J. Hammarström, Karolinska Institutet, Sweden
    The Delicate SAR of Cordycepins as Experimental Therapeutics for Human African Trypanosomiasis
  • Parasuraman Jaisankar, CSIR-Indian Institute of Chemical Biology, India
    3,3’-Diindolylmethane (DIM) as potent anti-leishmanial agent targeting DNA Topoisomerase 1B of Leishmania Donovani

 

11:15 - 12:00     Keynote Lecture II:
Shuh Narumiya, Kyoto University, Japan

"Academia-Industry Alliance for Drug Discovery and Development; Challenge and Experience of Kyoto University"

12:00 - 13:00     Lunch

 

13:00 - 14:00     Industry-Academic-Government Interaction in Drug Discovery
(Panel Discussion)

Co-chairs: Paul Bauer, Novartis, USA
Rathnam Chaguturu, SRI, USA


Panelists:

  • Paul Bauer, Novartis, USA
  • Tanya Parish, Infectious Disease Research Institute, USA
  • Bahne Stechmann, Germany
  • Tsutomu Kamiyama, Mitsubishi Tanabe Pharma and Kobe University, Japan
  • Rathnam Chaguturu, SRI, USA

 

14:00 - 15:50      Session IX: Chemical Approaches for Translational Sciences

Chair: Siddhartha Roy, Indian Institute of Chemical Biology, India

  • Mei Lin Go, National University of Singapore, Singapore
    Dibenzylidenethiopyranone Dioxides Induce APL Cell Apotosis by Proteasomal Inhibition and Activation of Endoplasmic Reticulum (ER) Stress Signaling Pathways
  • Ling-Hua Meng, Chinese Academy of Sciences, China
    Targeting PI3K-coupled MEK/ERK Pathway for Therapy in Pediatric B Cell Acute
    lymphocytic leukemia 
  • Tapas K. Kundu, Jawaharlal Nehru Centre for Advanced Scientific Research, India
    Chromatin Modifications in Neural Differentiation and Memory: Implications of Lysine Acetylation and Arginine Methylation

  • Zhong-Yin Zhang, Indiana University, USA
    Drugging the Undruggable: Therapeutic Potential of Protein Tyrosine Phosphatases
  • Guillaume Lessene, Walter and Eliza Hall Institute of Medical Research, Australia
    Small Molecules Interfering with Programmed Cell Death


15:50 - 16:00     Coffee/Tea Break


16:00 - 17:00     Session X: Global Rising Stars of Chemical Biology **special session**

Chair: Haian Fu, Emory University, USA

  • Bradley L. Pentelute, Massachusetts Institute of Technology, USA
    Novel Chemical Entities Introduced Into Cells via a Bacterial Transporter
  • Christian Ottmann, Eindhoven University of Technology, Netherlands
    Small-molecule Stabilization of 14-3-3 Protein-Protein Interactions
  • Xiaoguang Lei, National Institute of Biological Sciences, China
    Probing Programmed Cell Death with Bioactive Small Molecules  

 

17:30 - 17:50     Closing Lecture: "From Drugs to Genes: Implementing Target Free Approaches in Cancer Drug Discovery"

Ulf Nehrass, Franco-German Advanced Translational Center in Strasbourg (FGATC), France


17:50 - 18:00     Poster Awards, supported by CSBJ

 

18:00 - 18:15     Closing Remarks

 

 

 

 

 

ICBS2013 Conference Local Organizing Committee

  • Masatoshi Hagiwara (Kyoto University, Japan) -- Chair
  • Lixin Zhang (Chinese Academy of Sciences-- Co-Chair
  • Jonathan Baell (Monash University)
  • Nobutaka Fujii (Kyoto University)
  • Mei Lin Go (National University of Singapore)
  • Linghua Meng (Chinese Academy of Sciences)
  • Tetsuo Nagano (University of Tokyo)
  • Hiroyuki Osada (Riken)
  • Seung Bum Park(Seoul National University)
  • Siddhartha Roy (Indian Institute of Chemical Biology)
  • Motonari Uesugi (Kyoto University, Japan)


 

ICBS would like to thank the following sponsors for their generous support:

 

 

 

The Kyoto University Foundation

 

 

Kato Memorial Bioscience Foundation

 

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