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Scientific Program & Meeting Highlights
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Schedule & Speakers
 

 

 

 

 

 

 

 

 

 

 

 

Keynote addresses:

K. Barry Sharpless, 2001 Nobel Prize in Chemistry, The Scripps Research Institute, USA Biological applications of SuFEX click chemistry

 

Zixin Deng, Shanghai Jiao Tong University, Shanghai, China

Chemical Biology of S modifications

 

Rolf Müller, Helmholtz, Germany

Expanding antibiotic chemical space baed on bacterial biodiversity to fight antimicrobial resistance

 

Masatoshi Hagiwara, Kyoto University, Japan

RNA-targeting chemical therapeutics

 

ICBS President’s Forum to feature world thought leaders to focus on promoting chemical biology with synthetic biology

ICBS2017 presents cutting edge sciences by distinguished young chemical biologists

  • ICBS Young Chemical Biologists’ Forum (Oct 17, 2017)
  • Rising stars session by new ICBS Young Chemical Biologist awardees 2017 (competition open)
  • Podium Flash Presentations by selected poster presenters (1 min x >50)

                  Trainee travel award application open

Ten scientific sessions by more than 60 invited speakers from 15 countries

Special sessions to promote industrial interactions and global collaborations

  • Global chemical biology landscape – an update
  • Chemical biology in pharmaceutical industry

 

Major topics:

  • Molecular mechanisms of an active compound 
  • Drug resistance challenges: from microbial to cancer therapeutics
  • Interrogate diseases with chemical biology, including cancer, neurodegeneration, and neglected diseases
  • Chemical innovations for “undruggable” target space
  • Molecular biosensors and actuators
  • Expand the chemical space
  • New chemical modalities
  • Phenotypic investigation with chemical probes acids
  • Chemical biology of epigenetics, nucleic acids,  glycobiology an Ubiquitin signaling
  • In silico screening and computational design
  • Bioprocess in chemical biology
  • Emerging technologies in  in chemical biology
  • Chemical biology and pharmaceutical industry
  • Global chemical biology landscape

Podium presentations will be selected from submitted abstracts for each session.

 

Special events:

  • Rising stars session to feature ICBS Young Chemical Biologist awardees (link to past awardees)
  • Pre-meeting for young scientists and students (October 17, 2017)
  • Podium flash presentations for selected (~60) poster presentations
  • Educational workshops for chemical biologists

 

 

ICBS2017 Preliminary Program

(Meals stated are included in registration)

 

Day 1 - October 17, 2017

ICBS Young Chemical Biologists’ Forum (YCB as ICBS Young Chemical Biologist awardee)

Chairs: Xiaoguang Lei, (ICBS YCB2013), Peking University, Qi Zhang, Fudan University

 

A Shotgun Approach to Inquire Degradable Kinome

Li Tan, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China

 

XFEL for Structural Chemical Biology of GPCRs

Haitao Zhang, Zhejiang University, China

 

Stimuli-responsive Nucleic Acids as Potential Sensors and Drugs

Yu Xiang, Tsinghua University

 

Chemoproteomic Profiling Reveals the Anti-steatosis Mechanism of Traditional Chinese Medicine

Chu Wang, Peking University

 

Biosynthesis of PP2A inhibitor Rubratoxin A

Youcai Hu, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College

 

Mechanistic Studies of a Multifunctional 2-Oxoglutarate Dependent Non-heme Iron Enzyme, AsqJ

Yisong Guo, Carnegie Mellon University

 

Mechanistic Investigation of Radical S-adenosylmethionine Enzymes

Qi Zhang, Fudan University

 

Development of Far-red to Near-infrared Small-molecules Fluorophores and Their Application to Fluorescent Probes

Kenjiro Hanaoka (YCB2014), The University of Kokyo, Japan

 

Small-molecule Stabilization of Protein-protein Interactions

Christian Ottmann (YCB2013), Eindhoven University of Technology, Netherlands

 

Inspiration from Fluorination:  Chemical Biology Approaches to Probe Molecular Recognition Events in Transcription

William Pomerantz (YCB2016), University of Minnesota Twin Cities, USA

 

Regulation and Targeting of BAX-mediated Apoptosis

Evripidis Gavathiotis (YCB2015), Albert Einstein College of Medicine

 

Electrophysiology, Unplugged: Using Chemistry to Watch Cells in Action

Evan Miller (YCB2015), University of California- Berkeley, USA

 

3:00 pm           Wecome Ceremony & Group Photo

                        Chair: Lixin Zhang, ECUST

 

                        Keynote opening lecture

                        Chemical Biology of S modifications

                         Zixin Deng, Shanghai Jiao Tong University, Shanghai, China

 

                         Podium flash presentations for selected posters

                         Chair: Tom Pfeifer, CDRD, Canada

 

5:00 - 8:00 pm  Welcome Reception

 

 

Day 2 - October 18, 2017

ICBS President’s forum and Round table discussion:

Synthetic Biology to drive chemical biology and biotechnology

  • Sang Yup Lee, Korea Advanced Institute of Science and Technology, Korea
  • Jens Nielsen, Chalmers University of Technology, Sweden
  • Eriko Takano, University of Manchester, UK
  •  George Guo-Qiang Chen, Tsinghua University, China

        Next Generation Industrial Biotechnology based on Halophiles

  •  Haifeng Ye, East China Normal University, China

         Engineering of Optogenetic Designer Human Cells for Diabetes Therapy

 

Chemical innovations to expand chemical space and reach the undruggables

Session 1 - Expand the chemical space

Chairs:Jason Micklefield, The University of Manchester, UK and Huw Davies, Emory University, USA

 

Mechanistic studies of the cyclization reactions in the biosynthesis of spinosyn

Hung-wen (Ben) Liu, University of Texas at Austin, USA

 

Heterologous Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in Streptomyces

Eung-Soo Kim, Inha University, Korea

 

Diversification of bioactive natural and non-natural products using engineered biosynthetic pathways and enzymes

Jason Micklefield, The University of Manchester, UK

 

Genetically encoding phosphotyrosine and its nonhydrolyzable analog

Feng Wang, California Institute for Biomedical Research, USA

 

Beyond orthogonality, another good reaction for click chemistry

Jiajia Dong, Shanghai Institute of Organic Synthesis, China

 

Collaborative approaches for selective C-H functionalization

Huw Davies, Emory University, USA

 

Session 2 - Chemical biology to address undruggable targets

Chairs: Mel Reichman, Lankenau Institute for Medical Research, USA and Jiangyun Wang, Institute of Biophysics, Chinese Academy of Sciences, China

 

Exploring Complex Protein Structures and Protein-Protein Interactions with CXMS

Xiaoguang Lei (YCB2013), Peking University

 

Targeting E2/E3 ubiquitin ligase activity as a novel strategy to combat autoimmunity

Kamyar Hadian, Helmholz-Zentrum munchen, Germany

 

Metalloprotein design using genetic code expansion

Jiangyun Wang, Institute of Biophysics, Chinese Academy of Sciences, China

 

Therapeutic strategies to target tumor suppressors through protein interaction network

Andrei Ivanov, Emory University, USA

 

 

Day 3 - October 19, 2017

Addressing challenges in diseases with chemical biology

 

Session 3 - Determine molecular mechanisms of an active compound

Chair: Bridget Wagner, Broad Institute of MIT and Harvard, USA and Seung Bum Park, Seoul National University, Korea

 

Systematic approaches to small-molecule mechanism-of-action studies

Bridget Wagner, Broad Institute of MIT and Harvard, USA

 

Exploration of bioactive compounds, target identification and development of the new analytical methods

Hiroyuki Osada, RIKEN, Japan 

 

FITGE-based Target Identification: New Tool in Chemical Biology

Seung Bum Park, Seoul National University, Korea

 

Resistance Mechanisms to mTOR Kinase Inhibitors in Cancer

X.F. Steven Zheng, Rutgers Cancer Institute of New Jersey, USA

 

Session 4 - Interrogate diseases with chemical biology I

Chairs:  Guo-Qiang Chen, Shanghai Jiaotong University, China and Siddhartha Roy, Boss Institute, India

 

Cancer cell fate determination-based chemical biology investigation

GuoQiang Chen, Shanghai Jiaotong University, China

 

A general methodology for conversion of life-threatening viruses into live virus vaccines

Demin Zhou, Peking University, China

 

Design and development of slycosyltransferase inhibitors as novel anti-metastatic agents

Danielle Skropeta, University of Wollongong, Australia

 

Discovery of first-in-class specific small molecules antagonizing PXR (NR112) to overcome drug resistance in human cancers

Taosheng Chen, St Jude Children’s Research Hospital, USA

 

Novel small molecule MerTK inhibitors and their dual function in cancer treatment

Xiaodong Wang, The University of North Carolina at Chapel Hill, USA

 

Aglycone polyethers J1-001 and its homologues are effective to broad cancer cells

Tiangang Liu, Wuhan University, China

 

Session 5 - Interrogate diseases with chemical biology II

Chairs:  Hanne IngmerUniversity of CopenhagenDenmark and Cong Liu, Shanghai Institute of Organic Chemistry, China

 

Natural quorum quenching compounds targeting Staphylococcus aureus quorum sensing- implications for colonization and infection

Hanne Ingmer, University of Copenhagen, Denmark

 

Selective labelling and eradication of   antibiotic-tolerant populations in bacterial biofilms

Liang Yang, Nanyang Technological University, Singapore

 

Interplay between a-synuclein and lipids in Parkinson’s disease

Cong Liu, Shanghai Institute of Organic Chemistry, China

 

Novel mechanism of action of an anti-biofilm antibiotic

Chengzhang Fu, Helmholz-Zentrum ur infektionsforschung GmbHf, Germany

 

Protein Aggregation Small Molecule Inhibitor Discovery and Mechanisms

Bin Xu, Center for Drug Discovery, and School of Neuroscience, Virginia Tech, USA

 

Session 6 - Computational approaches to accelerate chemical biology research

Chairs: Luhua Lai, Peking University China and Petr Bartunek, Institute of Molecular Genetics, Czech Republic

 

Chemical and biological space exploration

Petr Bartunek, Institute of Molecular Genetics, Czech Republic

 

Structural Insights of Electron Transfer in P450 Monooxygenase

Jiahai Zhou, Shanghai Institute of Organic Synthesis, China

 

Rational Design of Protein Allosteric Regulators

Luhua Lai, Peking University China

 

Evolution of chemical similarity: from structure to activity

Paul A. Clemons, Broad Institute of MIT and Harvard, USA

GuoQiang Chen, Shanghai Jiaotong University, China

 

A general methodology for conversion of life-threatening viruses into live virus vaccines

Demin Zhou, Peking University, China

 

Design and development of slycosyltransferase inhibitors as novel anti-metastatic agents

Danielle Skropeta, University of Wollongong, Australia

 

Discovery of first-in-class specific small molecules antagonizing PXR (NR112) to overcome drug resistance in human cancers

Taosheng Chen, St Jude Children’s Research Hospital, USA

 

Novel small molecule MerTK inhibitors and their dual function in cancer treatment

Xiaodong Wang, The University of North Carolina at Chapel Hill, USA

 

Aglycone polyethers J1-001 and its homologues are effective to broad cancer cells

Tiangang Liu, Wuhan University, China

 


Day 4 - October 20, 2017

Chemical biology innovations and applications

 

Session 7  - Molecular biosensors and actuators

Chair: Jin Zhang, University of California San Diego, USA

 

NIR Fluorescent Organic Nanoprobes

Weihong Zhu, East China University of Science and Technology, China

 

Making gels in cells: total synthesis of stress granules by multivalent enhancers

Takanari Inoue, Johns Hopkins University, USA

 

Protein engineering and the development of intracellular biosensors

Robert Campbell, University of Alberta, Canada

 

Genetically encoded fluorescent sensors reveal dynamic regulation of redox metabolism in living cells

Yi Yang, East China University of Science and Technology, China

                 

Session 8 Biological insights with chemical biology

Chair:    Tapas Kundu, JCASR, India and Jonathan Baell, Monash University, Australia

 

Protein degradation based conditional knockout

Pinghua Liu, Boston University, USA

 

Crosstalk between epigenetic systems in bacteria

Shi Chen, Wuhan University, China

 

Chemical-assisted sequencing of epigenetic nucleic acid modifications

Chengqi Yi, Peking University, China

 

Chemical intervention of RNA methylation

Caiguang Yang, Shanghai Institute of Material Medica, China

 

Session 9 - New chemical modalities

Chairs: Xiyun Yan, Institute of Biological Physics, Chinese Academy of Sciences, China and Zhen Xi, Nankai University, China

 

Nanozyme: Discovery and its Applications in Medicine

Xiyun Yan, Institute of Biological Physics, Chinese Academy of Sciences, China

 

Chemoenzymatic glycan labeling: methods and applications

Peng Wu, John Hopkins University, USA

 

MetDNA: Recursive Metabolite Annotation and Dysregulated Network Analysis for Untargeted Metabolomics

Zhengjiang Zhu, Shanghai Institute of Organic Chemistry, China

 

Spatiotemporal Control Cellular Functions by Environment Stimuli-Induced Proximity

Wei Wang, East China University of Science and Technology, China

 

Session 10 - Emerging technologies

Chairs: Mikiko Sodeoka, RIKEN, Japan and Peng Chen, Peking University, China

 

Bioorthogonal cleavage reactions in living cells

Peng Chen, Peking University, China

 

Perturbation of microtubule function using designed peptides

Surajit Ghosh, CSIR-IICB, India

 

Smashing and Stapling: Chemical control of protein function through regulated polypeptide cleavage

Michael Lin, Stanford University, USA

 

Ribosome pausing at AT-rich codons regulates translation in Streptomyces tsukubaensis

Byung-Kwan Cho, Korea Advanced Institute of Science and Technology (KAIST), Republic of Korea

 

Turn-on fluorescent labeling using O-NBD unit

Mikiko Sodeoka, RIKEN, Japan

 

Closing keynote lecture

K. Barry Sharpless, 2001 Nobel Prize in Chemistry, The Scripps Research Institute, La Jolla, USA

“Biological applications of SuFEX click chemistry”

 

Evening

Closing ceremony, dinner, and performance

------------------------------------------------------------

Special sessions:

Rising stars in chemical biology: ICBS Young Chemical Biologist awards 2017

Presentations by awardees of ICBS YCB2017

 

Chemical biology in pharmaceutical industry

Chair: Christian Ottmann, Eindhoven University of Technology, Netherlands

Panelists: Yves Auberson, Novartis, Switzerland

Rathnam Chaguturu, iDDPartners, USA

Hong Shen, Roche Innovation Center, China

 

Global chemical biology landscape – an update

Chair: Masatoshi Hagiwara, University of Kyoto, Japan

 

The Japanese Society for Chemical Biology

Masatoshi Hagiwara, University of Kyoto, Japan

 

Chemical biology initiatives in China

Lihe Zhang, Peking University, China

 

Graduate Chemical Biology education in the US

Zaneta Nikolovska-Coleska, University of Michigan, USA

 

EU-OpenScreen and chemical biology in Europe

Bahne Stechmann, EU-OPENSCREEN, Berlin, Germany

 

Updates on chemical biology societies and activities around the globe

 

Conference chairs:

Zixin Deng (co-chair), Shanghai Jiao Tong University, Shanghai, China

Lixin Zhang (co-chair), East China University of Science and Technology, Shanghai, China

 

ICBS2017 Program/Organizing Committees

Zhen Xi  (Chair of Scientific Program Committee), Nankai University, Tianjin, China

Yingping Zhuang (Secretary), East China University of Science and Technology

Xu Li  (Chair of Outreach Committee), Oulan Inc., China

Hongzhuan Chen, Shanghai Jiaotong University, Shanghai, China

Peng Zhou, Wuhan University, Wuhan, China

Demin Zhou, Peking University, Beijing, China

Zongbao Zhao, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China

Zhaoyong Yang, The Institute of Medicinal of Biotechnology (IMB), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Xu Zhang, Nanjing University of Traditional Chinese Medicine, Nanjing, China

Chunyang Cao, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

Jiahai Zhou, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

Youli Xiao, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, China

Peng Chen, Peking University, Beijing, China

Qi Zhang, Fudan University, Shanghai, China

Shi Chen, Wuhan University, Wuhan, China

Minyong Li, Shandong University, Jinan, China

Xiang Zhou, Wuhan University

Xinshan Ye, Peking University

Lei Liu, Tsinghua University

Xiaoqi Yu, Sichuan University

Chunhai Fan, Shanghai Institute of Applied Physics, CAS

Chaoyong Yang, Xiamen University

Zhihong Jiang, Macao Univesity of Science and Technology

Dan Yang, Hongkong University

Zongwei Cai, Hongkong Baptist University

Weiming Dai, Hongkong University of Science and Technology

 

ICBS2017 International Advisory Committee:

Stuart Schreiber (co-chair), Harvard University/Broad Institute/HHMI, Boston, USA

Haian Fu (co-chair), Emory University, Atlanta, USA

Jonathan Baell, Monash University, Parkville, Australia

Petr Bartunek, Institute of Molecular Genetics, Prague, Czech Republic

Rathnam Chaguturu, iDDPartner, Princeton, USA

Kamyar Hadian, HelmholtzZentrum münchen GmbH, Munich, Germany

Masatoshi Hagiwara, Kyoto University, Kyoto, Japan

Hanne IngmerUniversity of CopenhagenDenmark

Pinghua Liu, Boston University, Boston, USA

Jason Micklefield, The University of ManchesterUK

Zaneta Nikolovska-Coleska, University of Michigan, Ann Arbor, USA

Christian Ottmann, Technische Universiteit Eindhoven, the Netherlands

Seung Bum Park, Seoul National University, Seoul, Korea

Tom Pfeifer, CDRD, Vancouver, Canada

Sally-Ann Poulsen, Griffith University, Brisbane, Australia

Siddhartha Roy, Boss Institute, Kolkata, India

Feng Wang, The Scripps Research Institute, San Diego, USA

Junying Yuan, Harvard Medical School, Boston, USA

Jin Zhang, University of California, San Diego, USA

Lihe Zhang, Peking University, China

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